Perinatal nutrition and immunity to infection

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Perinatal nutrition and immunity to infection.

Epidemiological data provide strong evidence for a relationship between undernutrition and life-threatening infection in infants and children. However, the mechanisms that underlie this relationship are poorly understood. Through foetal life, infancy and childhood, the immune system undergoes a process of functional maturation. The adequacy of this process is dependent on environmental factors,...

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Immunity to Measles, Mumps, and Rubella in US Children With Perinatal HIV Infection or Perinatal HIV Exposure Without Infection.

BACKGROUND Children with perinatal human immunodeficiency virus (HIV) infection (PHIV) may not be protected against measles, mumps, and rubella (MMR) because of impaired initial vaccine response or waning immunity. Our objectives were to estimate seroimmunity in PHIV-infected and perinatally HIV-exposed but uninfected (HEU) children and identify predictors of immunity in the PHIV cohort. METH...

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Human perinatal immunity in physiological conditions and during infection

The intrauterine environment was long considered sterile. However, several infectious threats are already present during fetal life. This review focuses on the postnatal immunological consequences of prenatal exposure to microorganisms and related inflammatory stimuli. Both the innate and adaptive immune systems of the fetus and neonate are immature, which makes them highly susceptible to infec...

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Perinatal nutrition and obesity.

Stimuli or insults during the perinatal period can have lifetime consequences and this long-term effect is called ‘programming’. Early nutrition is an important environmental signal that can induce lifetime effects on metabolism, growth and neurodevelopment and on major disease processes such as hypertension, diabetes, and obesity – . For instance, exclusive breast-feeding is an early environme...

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Nutrition and immunity with emphasis on infection and autoimmune disease.

Nutrition and nutritional status can have profound effects on immune functions, resistance to infection and autoimmunity in man and other animals. Nutrients enhance or depress immune function depending on the nutrient and level of its intake. Protein-energy malnutrition and vitamin A deficiency are strongly associated with impaired immunity and infectious disease. The essential role vitamin A p...

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ژورنال

عنوان ژورنال: Pediatric Allergy and Immunology

سال: 2010

ISSN: 0905-6157,1399-3038

DOI: 10.1111/j.1399-3038.2010.01002.x